Which pre-workouts are best? Many people take pre-workouts before they hit the gym to help increase their energy and motivation. This can lead to better results and, potentially, help you reach your conditioning goals more quickly. Anytime you are taking a supplement, it is always best to stick with reputable brands because they are not only proven to be effective but can also be relied on to use high-quality ingredients. For example, the company behind Cellucor C4 Original pre-workout has sold over 3 billion servings worldwide.