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Bookmark or Share- EnhancerAtlas 2.0: an updated resource with typical enhancer annotation ...Currently, the updated database contains 13,494,603 enhancers for 586 tissue/cell types. The database allows users to (1) examine the experimental evidence for the predicted enhancers in a given genomic region; (2) compare the enhancers across different cell/tissue types; (3) identify the enhancers associated with a particular gene; (4) predict ...
- Super-enhancers include classical enhancers and facilitators to fully ...Super-enhancers are compound regulatory elements that control expression of key cell identity genes. They recruit high levels of tissue-specific transcription factors and co-activators such as the Mediator complex and contact target gene promoters with high frequency.
- Mechanisms of enhancer action: the known and the unknownEnhancers are non-coding sequences in the genome that activate the expression of target genes transcribed by the RNA polymerase II (RNAPII). Enhancers can act independent of orientation, distance, and location with respect to the target gene and can be located over as much as a million base pairs away—as seen for the SHH gene .
- Enhancer (genetics) - WikipediaIn genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription of a particular gene will occur. [1][2] These proteins are usually referred to as transcription factors. Enhancers are cis -acting.
- Enhancers: five essential questions | Nature Reviews GeneticsSeveral fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent...
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