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Bookmark or Share- Mechanisms of enhancer action: the known and the unknownEnhancers are non-coding sequences in the genome that activate the expression of target genes transcribed by the RNA polymerase II (RNAPII). Enhancers can act independent of orientation, distance, and location with respect to the target gene and can be located over as much as a million base pairs away—as seen for the SHH gene .
- Enhancer (genetics) - WikipediaIn genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription of a particular gene will occur. [1][2] These proteins are usually referred to as transcription factors. Enhancers are cis -acting.
- Enhancers: five essential questions | Nature Reviews GeneticsSeveral fundamental questions need to be addressed about enhancers, such as how do we identify them all, how do they work, and how do they contribute to disease and evolution? Five prominent...
- Enhancers and silencers - Definition, Location, Examples, Functions ...Enhancers and silencers are key regulatory elements within genomes that control gene expression in metazoans. These elements play critical roles in ensuring that genes are turned on or off at the right times and in the right cells, which is essential for proper development and cellular function.
- Enhancers in disease: molecular basis and emerging treatment strategiesEnhancers are genomic sequences that play a key role in regulating tissue-specific gene expression levels. An increasing number of diseases are linked to impaired enhancer function through chromosomal rearrangement, genetic variation within enhancers, or epigenetic modulation.
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