Nicolas Ortega for BIJessica DeBenedetto has only been on compounded tirzepatide for a couple of weeks, but she already feels like it's a life-changer. Her doctor prescribed the cheaper, generic version of the weight-loss drug after her insurer refused to cover Zepbound, the brand-name version made by Eli Lilly. DeBenedetto, now 43, tells me she's been prediabetic since her 20s, and after going through hormone injections with IVF, she's put on a worrying amount of weight she just can't take off.