When psychedelic-assisted therapy becomes available in Colorado next year, the state will be just the second in the U.S. to regulate the production and use of psilocybin mushrooms. Oregon was the first state to legalize psilocybin therapy in 2020 and mental health-focused businesses there began offering it in 2023. Unsurprisingly, local regulators have looked to Oregon for guidance as they develop their own rules and regulations. There are already lessons to be learned.