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WASHINGTON — In a move Democrats denounced as trying to sabotage the Obama administration’s foreign policy, Sen. Rob Portman and 46 other Senate Republicans yesterday warned Iran’s leadership that any agreement to limit Tehran’s apparent efforts to build a nuclear bomb would need Senate approval to stay in effect beyond 2016.

House and Senate Republican leaders told President Barack Obama Thursday that they will refuse to nominate candidates to serve on an advisory board that is to play a role in holding down Medicare costs under the new health care act.

From the Appalachian trail to the campaign trail, former Governor Mark Sanford is back on the grid. After defeating Curtis Bostic in the GOP primary runoff on Tuesday, 57% to 43%, Sanford should be the favorite to win the vacated congressional seat in South Carolina first district. The district has become heavily Republican.

Republican Sen. Rand Paul said Tuesday that illegal immigrants should be allowed to become U.S. taxpayers and ultimately get a shot at citizenship, a significant step for the Tea Party favorite amid growing Republican acceptance of the idea.

Republican U.S. Sen. Rob Portman is now supporting gay marriage and says his reversal on the issue began when he learned one of his sons is gay. Ohio's junior senator disclosed his change of heart in interviews with several Ohio newspapers and CNN. In an op-ed published Friday in The Columbus Dispatch, he said the decision came after a lot of thought.

Twice burned, Republicans are treading carefully around tea party groups as they pursue a Senate majority that slipped through their fingers in 2010 and 2012....

When Sen. Tom Harkin (D-Iowa) announced Saturday that he wouldn’t seek a sixth term, Republicans rejoiced at the possibility of picking up the seat in 2014. But, that joy soon gave way to political reality — the likelihood of a primary between conservative, tea-party-aligned Rep. Steve King and a more establishment GOP figure such as Rep. Tom Latham or Lt. Gov. Kim Reynolds. And, just in case Republicans thought they might avoid that sort of primary fight, King released this statement Saturday night: “Iowans now have a real opportunity to elect a true Constitutional conservative.” (In case you were wondering, he is referring to himself.)

Indiana Republican Senate candidate Richard Mourdock said Wednesday that he is standing by his statement that when a woman becomes pregnant during a rape "that's something God intended." He says some people have twisted the meaning of his comment....

"Gov. Romney disagrees with Richard Mourdock, and Mr. Mourdock’s comments do not reflect Gov. Romney’s views," Romney campaign spokeswoman Andrea Saul said in an email. "We disagree on the policy regarding exceptions for rape and incest but still support him."

The FiveThirtyEight forecast model now gives Republicans just about a 16 percent chance of winning control of the Senate. This is a precipitous drop from just two months ago.