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MR-PRESSO (Mendelian Randomization Pleiotropy RESidual Sum and Outlier) is a method that allows for the evaluation of horizontal pleiotropy in multi-instrument Mendelian Randomization utilizing genome-wide summary association statistics.MR-PRESSO has three components, including: detection of horizontal pleiotropy (MR-PRESSO global test)correction of horizontal pleiotropy via outlier removal ... More @Wikipedia

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