Moisturizers and wrinkle creams that you can buy without a prescription aren't classified as medicine, so they aren't required to undergo scientific research to prove they work. If you're not happy with the results, talk with your healthcare team about moisturizers with prescription-strength anti-wrinkle ingredients, such as retinoids. Don't smoke. More @Wikipedia
Hover over any link to get a description of the article. Please note that search keywords are sometimes hidden within the full article and don't appear in the description or title.