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Bookmark or Share- A New Drug to Calm Agitation, Uncontrollable Laughing and ... - ALZFORUMIn a new Phase 2 trial, AVP-923, marketed as Nuedexta, reduced agitation scores in patients with Alzheimer’s. In a separate open-label study, the drug dampened the emotional outbursts of laughing and crying that sometimes afflict patients with dementia. Scientists do not know exactly how AVP-923 works for agitation.
- Aberrant excitatory neuronal activity and compensatory ... - ALZFORUMValproate seemed potentially useful because it is known to affect the brain. Along these lines, it could be considered that β amyloid could increase the excitability in neural networks, and reduction of that excitability could reduce the predilection for tauopathy to develop.
- Valproate - ALZFORUMValproate is an anti-convulsant and mood-stabilizing drug that is FDA- and EMA-approved to treat seizures, manic episodes associated with bipolar disorder, and to prevent migraine headaches. It is also used off-label for other psychiatric conditions. Valproate products include valproate sodium, divalproex sodium, valproic acid, and generic ...
- Therapeutics - ALZFORUMTherapeutics. This database provides a catalog of the therapeutics currently or previously tested as treatment for Alzheimer's disease and related disorders, focusing on those that have progressed to Phase 2 or beyond in U.S. clinical trials. We strive to keep this database up-to-date and welcome you to contact us at therapeutics@alzforum.org.
- Citalopram Calms Agitation in Alzheimer’s, but Carries RisksOther alternatives tested so far, such as donepezil and antiepileptics like valproate, have failed to show a benefit (see Oct 2007 news story; Nov 2009 conference story). Previous studies hinted that citalopram, a selective serotonin reuptake inhibitor (SSRI), helped calm elderly patients who had dementia or anxiety (see, e.g., Nyth and ...
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