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Bookmark or Share- Where to Now, Phospho-Tau? - ALZFORUMPlasma p-tau181 and p-tau217 values of 1.56 pg/mL and 0.25 pg/mL, respectively, or greater, predicted amyloid-positivity with specificities of 92 percent and 96 percent, respectively. Alas, sensitivities were low, around 50 percent, meaning the algorithm missed half of the people who did have brain amyloid.
- htau - ALZFORUMTau knockout mice were generated by targeted disruption, in which cDNA for enhanced green fluorescent protein (EGFP) was inserted into exon one of MAPT. Htau mice express six isoforms of human tau, but do not express mouse tau. Unlike the double mutant, neither 8c mice nor tau knockout mice develop tau pathology in the CNS. Neuropathology
- JNPL3(P301L) - ALZFORUMAs originally described, the hemizygous animals express human tau at levels comparable to endogenous murine tau, whereas homozygotes express human tau at approximately twice endogenous levels. Transgene expression was strongest in the cerebellum and hippocampus, followed by the thalamus, hypothalamus, spindal cord, brainstem and cortex.
- Tau, Speckle Wrecker, Disrupts the Nuclear Home - ALZFORUMThe researchers propose that tau’s speckle-wrecking proclivities underlie splicing defects that are reportedly rampant in tauopathies, including Alzheimer’s disease. In cells and mice, tau aggregates interact with nuclear speckle components. This disrupts mRNA splicing. Small RNAs and their binding proteins rerouted to the cytoplasm in ...
- Plasma p-Tau217 Set to Transform Alzheimer’s DiagnosticsThe paper by Palmqvist et al. on blood plasma phospho-tau 217 is a remarkable clinical study clearly demonstrating the value of phospho-tau 217 for identifying AD pathology. These findings advance our understanding of how p-tau217 is related to amyloid and tau PET and the stages of AD, and how it can be utilized as a blood biomarker.
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