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Bookmark or Share- Women’s techniques for making vaginal penetration more ... - PLOSHensel DJ, Schick V, Herbenick D, Dodge B, Reece M, Sanders SA, et al. Lifetime Lubricant Use among a Nationally Representative Sample of Lesbian‐and Bisexual‐Identified Women in the U nited S tates. The Journal of Sexual Medicine. 2015;12(5):1257–66. pmid:25974238 . View Article PubMed/NCBI
- AviTrap: A novel solution to achieve complete biotinylationIntroduction. Biotin is a water-soluble B vitamin that is ubiquitous in all living organisms. It is a crucial cofactor for carboxylase enzymes that facilitate the transfer of CO 2 groups during biosynthesis [].Biotin binds to the chicken egg white protein avidin and the homologous protein streptavidin with extremely high affinity (dissociation constant K D = 10 −15 M) and specificity [].
- Pembrolizumab 400 mg every 6 weeks as first-line therapy for advanced ...Intravenous pembrolizumab 400 mg every 6 weeks was approved across tumor types based on pharmacokinetic modeling, which showed exposures consistent with previous standard dosing of 200 mg or 2 mg/kg every 3 weeks, and early results of cohort B of the phase 1 KEYNOTE-555 study. Results after ≥1 year of potential follow-up for all patients in cohort B of KEYNOTE-555 are presented. Patients ...
- Cross-species regulatory sequence activity predictionMulti-genome training improves gene expression prediction accuracy. We applied the Basenji software and framework to predict functional genomics signal tracks from only DNA sequence [].The neural network takes as input a 131,072(= 2 17) bp sequence, transforms its representation with iterated convolution layers, and makes predictions in 128 bp windows across the sequence for the normalized ...
- TATES: Efficient Multivariate Genotype-Phenotype Analysis for ... - PLOSMultivariate genotype–phenotype methods do exist but attain maximal power only in special circumstances. We present a new multivariate method called TATES (Trait-based Association Test that uses Extended Simes procedure).
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