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Bookmark or Share- A Biological Definition of Parkinson’s Disease: Two ... - ALZFORUMIn SynNeurGe, Parkinson’s disease is classified by the presence or absence of disease-associated genetic variants (Gf, Gp, or G-), α-synuclein pathology (S+/S-), and PD-associated neurodegeneration (N+/N-). Clinical status is classified separately. Green bars indicate physiological conditions; other colors indicate pathogenic conditions.
- New PET Ligand Captures α-Synuclein in Parkinson’s, MSA BrainsA new PET ligand, C05-05, binds α-synuclein fibrils. It lit up the midbrain in PD and DLB; the putamen and cerebellum in MSA. High midbrain C05-05 uptake correlated with worse motor symptoms. “That C05-05 images α-synuclein in PD demonstrates the target density is high enough to see with PET, a question that has been raised for years ...
- Spying on α-Synuclein Inclusions: PET Tracers Inch Closer ... - ALZFORUM04 Aug 2023. PET tracers that illuminate α-synuclein in the brain have been hard to come by, but scientists may be getting closer. According to a study published August 3 in Cell, an 18F- tracer developed at Emory University, Atlanta, binds to α-synuclein aggregates in human Parkinson’s disease brain samples, in mouse models of ...
- Human Cell Models Reveal Two Sides to α-Synuclein Inclusions20 Sep 2024. Not all α-synuclein inclusions are created equal. That’s the upshot from a new stem cell approach to study “inclusionopathies,” such as Parkinson’s and Alzheimer’s diseases. As reported in the September issue of Neuron, scientists led by Vikram Khurana at Brigham and Women’s Hospital in Boston honed a method to rapidly ...
- Not All Bad: Phosphorylated α-Synuclein Modulates ... - ALZFORUMThe novel findings presented in the two papers, which suggest that normal α-synuclein has functions under physiological conditions, are quite interesting and unexpected. We had reported in 2002 that aggregated α-synuclein, but not the normal soluble species, is exclusively and highly phosphorylated at Ser129 (Fujiwara et al., 2002). Our ...
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