Sirt1 | search
Click here to view Sirt1 news from 60+ newspapers.
Bookmark or Share- Mechanisms and Memory: The Choreography of CREB, the Balance ... - ALZFORUMIn the SIRT1 KOs, higher expression of miRNA-134 inhibits CREB production, and ultimately leads to less BDNF in the brain. To nail down this mechanism, the authors showed that the presence of excess miRNA-134 in wild-type mice could abolish LTP and impair memory, and that knockdown of miRNA-134 in SIRT1 KO mice was sufficient to rescue LTP and ...
- BPN14770 | ALZFORUMBPN14770 antagonized the amnestic effect of the anti-nausea drug scopolamine, whereby two weeks’ dosing boosted hippocampal phospho-CREB and BDNF, markers of memory consolidation. A subsequent study implicated cAMP-PKA-SIRT1-Akt -Bcl-2/Bax signaling in BPN14770's anti-scopolamine effect in these mice (Zhang et al., 2018; Wang et al, 2020). In ...
- Semaglutide - ALZFORUMSemaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway. Neuropharmacology. 2023 Dec 1;240:109716. Epub 2023 Sep 18 PubMed. Zhang Y, Tang C, He Y, Zhang Y, Li Q, Zhang T, Zhao B, Tong A, Zhong Q, Zhong Z.
- A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine ... - ALZFORUMWang Y, Gao S, Zheng V, Chen L, Ma M, Shen S, Qu J, Zhang H, Gurney ME, O'Donnell JM, Xu Y.A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway.
- Edaravone - ALZFORUMOverview. Name: Edaravone Synonyms: MCI-186, Radicava®, Radicut®, MT-1186, FAB122 Therapy Type: Small Molecule Target Type: Other Condition(s): Amyotrophic Lateral Sclerosis U.S. FDA Status: Amyotrophic Lateral Sclerosis (Phase 4) Company: Mitsubishi Tanabe Pharma Approved for: Amyotrophic Lateral Sclerosis
More
