To remove or destroy by firing or projecting a missile: shot out the window. c. To make (a hole, for example) by firing a weapon. 2. To fire or let fly (a missile) from a weapon. 3. a. To discharge (a weapon). b. To detonate or cause to explode: shot off a firecracker. 4. To inject (a drug, for example) with a hypodermic syringe. 5. More @Wikipedia
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