Parp Inhibitors | search
Click here to view Parp Inhibitors news from 60+ newspapers.
Bookmark or Share- DNA damage response inhibitors in cancer therapy: lessons from ... - NatureThis paper explores the role of PARP in DNA SSBR and is the first to describe the phenomenon in which inactive PARP (in the absence of substrate NAD + or in the presence of an inhibitor) has a ...
- Poly(ADP-ribose) polymerase inhibition: past, present and futureEfforts to identify and evaluate potent PARP inhibitors have so far led to the regulatory approval of four PARP inhibitors for the treatment of several types of cancer, and PARP inhibitors have...
- PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor ...PARP inhibitors (PARPi) were the first approved cancer drugs that specifically targeted the DNA damage response in BRCA1/2 mutated breast and ovarian cancers.
- PARP inhibitor - WikipediaPARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. [1] Several forms of cancer are more dependent on PARP than regular cells, making PARP (PARP1, PARP2 etc.) an attractive target for cancer therapy.
- PARP Inhibitors | Targeted cancer drugs | Cancer Research UKAs a cancer treatment, PARP inhibitors stop the PARP from doing its repair work in cancer cells and the cell dies. Researchers first looked at these drugs in cancers that already had problems repairing cell damage.
More
