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Bookmark or Share- PARP Inhibitors as Initial Treatment for Ovarian CancerDrugs known as PARP inhibitors are used to treat some women with advanced ovarian cancer that has returned after earlier treatment. Now, results from three new clinical trials show that the drugs might also benefit women who are newly diagnosed with advanced ovarian cancer.
- Eisbach Bio positions HRD-targeting therapy to supplant PARP inhibitorsThe mechanism of action for EIS-12656 is similar to PARP inhibitors, but it is one step further downstream, said Schomburg. The small molecule works by inhibiting ALC1 (chromodomain-helicase-DNA-binding protein 1-like), a chromatin remodeller and DNA helicase also involved in DNA repair. In what Schomburg terms a “’winner takes all ...
- The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective ...PARP (poly-ADP ribose polymerase) has received widespread attention in cancer treatment. Research has shown that PARP plays a crucial role in DNA damage repair and has become a popular target for drug design. Based on the mechanism of “synthetic lethality”, multiple PARPis (PARP inhibitors) have been launched for the treatment of BRCA deficient tumors. For example, the approved PARPis have ...
- PARP inhibitor - WikipediaPARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. [1] Several forms of cancer are more dependent on PARP than regular cells, making PARP (PARP1, PARP2 etc.) an attractive target for cancer therapy.
- An Overview of PARP Inhibitors for the Treatment of Breast CancerThese BC susceptibility genes encode proteins critical for DNA homologous recombination repair (HRR). This review provides an update on oral poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of BC.
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