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Bookmark or Share- P-tau217 correlates with neurodegeneration in Alzheimer's ... - PubMedHere, we developed a monoclonal antibody (mAb2A7) against 217 site-phosphorylated human tau (p-tau217) and observed that p-tau217 levels positively correlated with brain atrophy and cognitive impairment in AD patients.
- Highly accurate blood test for Alzheimer’s disease is similar or ...Plasma %p-tau217 was clinically equivalent to FDA-approved CSF tests in classifying Aβ PET status, with an area under the curve (AUC) for both between 0.95 and 0.97. Plasma %p-tau217...
- Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for ...This study highlights the effectiveness of a commercially available plasma p-tau217 assay in identifying AD pathology. Our findings demonstrate the substantial reduction of confirmatory testing, by approximately 80%, by implementing a 3-range approach for Aβ positivity based on plasma p-tau217.
- Clinical application of plasma P-tau217 to assess eligibility for ...Plasma tau phosphorylated at threonine-217 (P-tau217) presents a promising alternative, yet optimal cutoffs for treatment eligibility with DMTs like aducanumab require further investigation. This study evaluates the efficacy of one- and two-cutoff strategies for determining DMT eligibility at the Butler Hospital Memory & Aging Program (MAP).
- Performance of plasma p-tau217 for the detection of amyloid-β ...Plasma p-tau217 has emerged as the most promising blood-based marker (BBM) for the detection of Alzheimer Disease (AD) pathology, yet few studies have evaluated plasma p-tau217 performance in memory clinic settings.
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