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Bookmark or Share- Improved human brain organoids to boost neurological disease researchOrganoids offer great promise for studying disease in humans directly. But so far, they have failed in one very important way. “We might all use our brains differently, but each of us has the same collection of cell types and basic connections,” explained senior author Paola Arlotta, the Golub Family Professor of Stem Cell and Regenerative ...
- Organoids: A new window into disease, development and discovery ...Organoids grow from stem cells—cells that can divide indefinitely and produce different types of cells as part of their progeny. Scientists have learned how to create the right environment for the stem cells so they can follow their own genetic instructions to self-organize, forming tiny structures that resemble miniature organs composed of ...
- Paola Arlotta, Ph.D. | Harvard Stem Cell Institute (HSCI)These organoids can achieve advanced neuronal maturation and the generation of spontaneously-active neuronal networks sensitive to sensory stimuli. By creating organoids bearing mutations in different risk genes for Autism Spectrum Disorder (ASD), we have uncovered cell-type-specific neurodevelopmental abnormalities that are shared across ASD ...
- Improving skin organoids | Harvard Stem Cell Institute (HSCI)The organoids also produced Merkel cells, specialized touch-responsive cells of the skin that have been implicated in diseases such as Merkel cell carcinoma. “The inclusion of these other cell types likely expands the potential uses of the skin organoid model to research on sensory disorders and cancer,” she added. Transplanting skin organoids
- Brain organoids replicate key events in human brain development ...Organoids are particularly useful for studying human development, where standard approaches used to study other animals can’t be used. But some scientists have previously questioned whether a brain organoid’s culture dish could serve as a realistic stand-in for the complex milieu of the human brain.
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