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Bookmark or Share- Hepatitis C virus nonstructural protein 5A - WikipediaNonstructural protein 5A (NS5A) is a zinc-binding and proline-rich hydrophilic phosphoprotein that plays a key role in Hepatitis C virus RNA replication. [1][2] It appears to be a dimeric form without trans -membrane helices. [3]
- NS5A - HCV Proteins - Hepatitis C OnlineNonstructural protein 5A (NS5A) is an essential component of the HCV replication complex. The NS5a protein interacts with other key viral products (NS4B, NS5B, RNA) and host cell proteins (cyclophilin A, kinases, etc.) to regulate viral replication and assembly.
- Discovery and development of NS5A inhibitors - WikipediaNS5A inhibitors have been developed to target the NS5A protein. These inhibitors have achieved a significant reduction in HCV RNA blood levels and can therefore be considered as potent antivirals. Their mechanism of action is thought to be diverse but the exact mechanism is not fully understood.
- Potent hepatitis C inhibitors bind directly to NS5A and reduce its ...A new class of agents has recently been developed that are believed to target the HCV protein NS5A although precisely where they interact and how they affect function is unknown.
- Hepatitis C Virus Nonstructural Protein 5A (NS5A) Is an RNA-binding ...Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to antagonize numerous cellular pathways, including the antiviral interferon-α response. However, the capacity of this protein to interact with the viral polymerase suggests a more direct role for NS5A in genome replication.
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