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Bookmark or Share- NS5A - HCV Proteins - Hepatitis C OnlineNonstructural protein 5A (NS5A) is an essential component of the HCV replication complex. The NS5a protein interacts with other key viral products (NS4B, NS5B, RNA) and host cell proteins (cyclophilin A, kinases, etc.) to regulate viral replication and assembly.
- Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core ...Nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) possesses multiple and diverse functions in RNA replication, interferon resistance, and viral pathogenesis.
- HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus ...The hepatitis C virus (HCV) non-structural 5A (NS5A) protein has generated wide interest in HCV research because of its ability to modulate the host cell interferon (IFN) response. The protein is phosphorylated on multiple sites by host cell kinases and interacts with host cell membranes.
- Hepatitis C virus nonstructural protein 5A - WikipediaNonstructural protein 5A (NS5A) is a zinc-binding and proline-rich hydrophilic phosphoprotein that plays a key role in Hepatitis C virus RNA replication. [1][2] It appears to be a dimeric form without trans -membrane helices. [3]
- Discovery and development of NS5A inhibitors - WikipediaNS5A inhibitors have been developed to target the NS5A protein. These inhibitors have achieved a significant reduction in HCV RNA blood levels and can therefore be considered as potent antivirals. Their mechanism of action is thought to be diverse but the exact mechanism is not fully understood.
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