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Bookmark or Share- Nrf2 and Oxidative Stress: A General Overview of Mechanisms and ...Nuclear factor erythroid 2-related factor 2 (Nrf2) is the transcriptional master regulator of cellular responses against oxidative stress.
- NRF2, a Transcription Factor for Stress Response and BeyondThe transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is best known as one of the main orchestrators of the cellular xenobiotic and oxidative stress response.
- NFE2L2 - WikipediaNFE2L2, also known as NRF2, is a protein that regulates the expression of genes involved in antioxidant defense, metabolism, inflammation, and other processes. Learn about its structure, function, regulation, and role in diseases and drugs.
- Nrf2 signaling pathway: Pivotal roles in inflammationNrf2 belongs to the Cap ‘n’ Collar (CNC) subfamily and comprises in seven functional domains, Neh (Nrf2-ECH homology) 1 to Neh7 [9], [10].Neh1 is a CNC-bZIP domain that allows Nrf2 to heterodimerize with small musculoaponeurotic fibrosarcoma (Maf) protein, DNA, and other transcription partners as well as forming a nuclear complex with the ubiquitin-conjugating enzyme UbcM2 [11], [12].
- The regulation and function of Nrf2 signaling in ferroptosis ... - NatureThe key anti-oxidative transcription factor, nuclear factor E2 related factor 2 (Nrf2 or NFE2L2), plays a dominant role in defense machinery by reprogramming the iron, intermediate, and...
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