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Bookmark or Share- Intepirdine as adjunctive therapy to donepezil for mild-to-moderate ...Intepirdine as adjunctive therapy to donepezil for mild-to-moderate Alzheimer's disease: A randomized, placebo-controlled, phase 3 clinical trial (MINDSET). Alzheimers Dement (N Y). 2021;7(1):e12136. Epub 2021 May 31 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment
- Intepirdine - ALZFORUMOriginally developed by GSK under the name SB-742457, RVT-101/intepirdine is an antagonist of the serotonin receptor 6 (5-HT)6, a largely CNS-specific member of the serotonin receptor subfamily. The serotonergic neurotransmitter system is impaired as Alzheimer’s develops and progresses, and modulating it is seen as a potential therapeutic ...
- Masupirdine - ALZFORUMIntepirdine; Idalopirdine; Dimebon; PF-05212377 ; Paper Citations. Nirogi R, Mudigonda K, Bhyrapuneni G, Muddana NR, Goyal VK, Pandey SK, Palacharla RC. Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, SUVN-502, in Healthy Young Adults and Elderly Subjects. Clin Drug Investig. 2018 May;38(5):401-415. PubMed
- Intepirdine Joins the Ranks of Failed Alzheimer’s DrugsAdditionally, they received a daily oral dose of either 35 mg intepirdine or placebo for 24 weeks. At the end of the trial, treated patients showed no statistically significant improvement in either primary endpoint, the ADAS-Cog, or the Alzheimer's Disease Cooperative Study-Activities of Daily Living scale (ADCS-ADL).
- Therapeutics | ALZFORUMThis database provides a catalog of the therapeutics currently or previously tested as treatment for Alzheimer's disease and related disorders, focusing on those that have progressed to Phase 2 or beyond in U.S. clinical trials.
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