Yes I've created an imposition file and set it to saddle stitch, finished size 8.5 x 11, and press sheet as 11x17. It says the pages don't fit the layout, so I have to change it to 17x11 (Ledger) in order for it to put the 2 pages up properly. The variable data text box is on the first page of each 28 page document. More @Wikipedia
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