Definition of 'goofball' goofball in American English. (ˈgufˌbɔl ) US. noun Slang. 1. a pill containing a barbiturate or, sometimes, a stimulant drug, tranquilizer, etc., esp. when used nonmedicinally. : also goof ball. 2. goof (sense 1) adjective. 3. goofy. Webster’s New World College Dictionary, 4th Edition. More @Wikipedia
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