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Bookmark or Share- Roles of galectins in infection - Nature Reviews MicrobiologyThis Review discusses the role of galectins in microbial infection, with particular emphasis on adaptations of pathogens to evasion or subversion of host galectin-mediated immune responses.
- Galectin TherapeuticsGalectin Therapeutics develops novel therapies to improve the lives of patients with chronic liver disease and cancer. Galectin’s lead drug, belapectin (GR‑MD‑02), is a carbohydrate-based drug that inhibits the galectin‑3 protein, involved in many inflammatory, fibrotic, and malignant diseases.
- Galectin - WikipediaGalectins are a class of proteins that bind specifically to β-galactoside sugars, such as N -acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding.
- Galectins: structure, function and therapeutic potentialGalectins are a family of animal lectins that bind β-galactosides. Outside the cell, galectins bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular processes.
- The role of galectins in immunity and infection - NatureGalectins can be located in the nucleus or the cytoplasm, or can be secreted into the extracellular space. They can modulate innate and adaptive immune cells by binding to glycans on the surface...
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