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Bookmark or Share- Inactivation of the Fto gene protects from obesity | NatureVariations in the human FTO gene have been linked to obesity-related traits in several genome-wide association studies. A functional correlation is now reported between Fto, the equivalent gene...
- FTO gene - WikipediaBy exon trapping, Peters et al. (1999) cloned a novel gene from a region of several hundred kb deleted by the mouse 'fused toes' (FT) mutation. They named the gene 'fatso' (Fto) due to its large size. [46] [47]
- Obesity and FTO: Changing Focus at a Complex Locus - Cell PressThe fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity. Murine models of perturbed Fto expression have shown effects on body weight and composition.
- The ‘Fat Mass and Obesity Related’ ( FTO ) gene: Mechanisms of Impact ...A cluster of single nucleotide polymorphisms (SNPs) in the first intron of the fat mass and obesity related (FTO) gene were the first common variants discovered to be associated with body mass index and body fatness.
- FTO – A Common Genetic Basis for Obesity and CancerMutations in the FTO gene raise blood levels of leptin, a known mediator or growth factor between obesity and colon cancer, which activates a variety of pathways associated with colon cancer (Drew, 2012; Mehrdad et al., 2020a).
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