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Bookmark or Share- CD3 - MyPathologyReport.caCD3 is a protein that is normally made by two types of specialized immune cells, T cells and NK cells. Most lymphomas that start from T and NK cells, including peripheral T cell lymphoma, anaplastic large cell lymphoma, and extranodal NK/T cell lymphoma, also make CD3.
- Pathology Outlines - CD3CD3 is expressed as either TCR alpha / beta or TCR gamma / delta heterodimers, coexpressed at cell surface with the TCR complex (Immunity 2006;24:133) CD3 is first expressed in the cytoplasm of developing T cells, then as they mature it moves to the membrane ( Immunity 2006;24:133 )
- Modulating T Cell Responses by Targeting CD3 - PMCCD3 is a multimeric protein complex comprising three different subunits: CD3δε, CD3γε, and CD3ζζ dimers. Homologous CD3δε and CD3γε are heterodimers with single extracellular immunoglobulin domains that interact with the TCR α and β chains and have relatively short intracellular signaling domains.
- CD3-specific antibodies: a portal to the treatment of autoimmunity - NatureCD3-specific monoclonal antibodies inactivate pathogenic cells by inducing rapid internalization of the T-cell receptor (TCR)–CD3 complex from the cell surface.
- What is CD3? - MabtechCD3 (cluster of differentiation 3) is a T cell co-receptor that plays an important role in T cell activation and signal transduction. The CD3 complex is composed of four chains: two CD3ε, one CD3γ, and one CD3δ chain.
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