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Bookmark or Share- Helicobacter pylori - WikipediaCagA (cytotoxin-associated antigen A) is a major virulence factor for H. pylori, an oncoprotein that is encoded by the cagA gene. Bacterial strains with the cagA gene are associated with the ability to cause ulcers, MALT lymphomas, and gastric cancer.
- Mechanism of regulation of the Helicobacter pylori Cagβ ...The transport of the CagA effector into gastric epithelial cells by the Cag Type IV secretion system (Cag T4SS) of Helicobacter pylori (H. pylori) is critical for pathogenesis.
- The Role of CagA in the Gastric Biology of Helicobacter pyloriThe enhanced host interactions of cagA + strains drive proliferative, inflammatory, and immune phenomena not only in vitro but also in vivo, which is a double-edged sword. In short, the CagA molecular interactions create a state of chronic inflammation that injures the stomach, which worsens across the decades, leading to atrophy and metaplasia ...
- Molecular anatomy and pathogenic actions of - NatureChronic infection with Helicobacter pylori cagA -positive strains is the strongest risk factor for gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via...
- CagA-mediated pathogenesis of Helicobacter pylori - PubMedThe major pathological feature of H. pylori infection is due to the activity of the cytotoxin-associated gene A (CagA), a 125-140 kDa protein encoded by the cag pathogenicity island (cagPAI). CagA is also known as the first bacterial onco-protein, ranking the H. pylori-mediated adenocarcinoma as the second most deadly cancer type worldwide.
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