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Bookmark or Share- PALB2 and Associated Cancer Risks (PDQ®) - NCIPALB2 is emerging as the second-most commonly mutated gene in male breast cancer, after BRCA2. Pancreatic Cancer Risk Associated with PALB2 Pathogenic Variants. A study first reported a PALB2 pathogenic variant in an individual with familial pancreatic cancer in 2009 using exome sequencing.
- Surgery to Reduce the Risk of Breast Cancer Fact SheetThis surgery is often used to reduce the risk of ovarian and fallopian tube cancer in those who are at high risk for the disease because of inherited harmful changes in BRCA1, BRCA2, and several other genes.
- Mutaciones en el gen BRCA: el riesgo de cáncer y las pruebas genéticasHoja informativa sobre los genes BRCA1 y BRCA2, qué hacer si la prueba de una persona indica que tiene cambios en uno de estos genes y las consecuencias de las pruebas genéticas.
- Genetic Testing Fact Sheet - NCI - National Cancer InstituteGenetic testing can give several possible results: positive, negative, true negative, uninformative negative, or variant of uncertain significance (VUS).. Positive result. A positive test result means that the laboratory found a genetic change that is associated with an increased cancer risk. Such harmful genetic changes are called pathogenic or likely pathogenic variants.
- BRCA Gene Changes: Cancer Risk and Genetic TestingA fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.
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