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Bookmark or Share- The BMJ: Leading Medical Research, News, Education, OpinionHigh impact medical journal. Champion of better research, clinical practice & healthcare policy since 1840. For GPs, hospital doctors, educators, policymakers.
- Global health: where do cardiologists fit in? | HeartThe United Nations (UN) Sustainable Development Goals aim to reduce deaths from non-communicable diseases by one-third by 2030. In addition, the member states of the UN have agreed in principle to take action to decrease cardiovascular disease (CVD)-related mortality by 25% by 2025.1 While there was a decrease in age-specific deaths globally from 2007 to 2017, total CVD deaths rose by 21% ...
- Nemvaleukin alfa, a modified interleukin-2 cytokine, as monotherapy and ...Background Nemvaleukin alfa (nemvaleukin, ALKS 4230) is a novel, engineered cytokine that selectively binds to the intermediate-affinity interleukin-2 receptor, preferentially activating CD8+ T cells and natural killer cells, with minimal expansion of regulatory T cells, thereby mitigating the risk of toxicities associated with high-affinity interleukin-2 receptor activation. Clinical outcomes ...
- Association of DCIS size and margin status with risk of ... - The BMJObjective To examine the association between size and margin status of ductal carcinoma in situ (DCIS) and risk of developing ipsilateral invasive breast cancer and ipsilateral DCIS after treatment, and stage and subtype of ipsilateral invasive breast cancer. Design Multinational, pooled cohort study. Setting Four large international cohorts. Participants Patient level data on 47 695 women ...
- Role of maternal age and pregnancy history in risk of ... - The BMJResults There were 421 201 pregnancies during the study period. The risk of miscarriage was lowest in women aged 25-29 (10%), and rose rapidly after age 30, reaching 53% in women aged 45 and over. There was a strong recurrence risk of miscarriage, with age adjusted odds ratios of 1.54 (95% confidence interval 1.48 to 1.60) after one miscarriage, 2.21 (2.03 to 2.41) after two, and 3.97 (3.29 to ...
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