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Bookmark or Share- Age and sex differences in soluble ACE2 may give insights for COVID-19ADAM-17 (a disintegrin and metalloproteinase-17), during physiological conditions and in SARS-CoV infection, can cleave mACE2, resulting in shedding and soluble ACE2 (sACE2) [2, 3], a process also associated with ALI (acute lung injury) . High mACE2 and/or high ADAM-17 activity may therefore facilitate SARS CoV-2 infection and severe COVID-19 ...
- Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19ACE2 is expressed in nearly all human organs in varying degrees. In the respiratory system, the traditional immunohistochemical method and recently introduced single-cell RNA-seq analysis revealed that ACE2 is mainly expressed on type II alveolar epithelial cells, but weakly expressed on the surface of epithelial cells in the oral and nasal mucosa and nasopharynx, indicating that the lungs are ...
- Recombinant ACE2 protein protects against acute lung injury induced by ...Recombinant ACE2 protein (rACE2) has been demonstrated to play protective role against SARS-CoV and avian influenza-induced ALI, and more relevant, rACE2 inhibits SARS-CoV-2 proliferation in vitro. However, whether rACE2 protects against SARS-CoV-2-induced ALI in animal models and the underlying mechanisms have yet to be elucidated.
- The alternative renin–angiotensin system in critically ill patients ...The protective role of ACE2 was further supported by the use of active recombinant human ACE2 (rhACE2) protein as a rescue therapy for acid-induced acute lung injury (ALI). rhACE2 was associated with a decrease in the severity of experimental ALI, as evidenced by reduced changes in lung elastance and a decreased wet-to-dry ratio compared to ...
- ACEI/ARB therapy in COVID-19: the double-edged sword of ACE2 and SARS ...Yet, ACE2 is the main receptor for binding and uptake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the cell. Indeed, in vitro data support the concept that respiratory epithelium, which appears to be the main route of SARS-CoV-2 entry into the body, has multiple cell types with high ACE2 expression [ 1 ].
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