The first is regulatory issues, which can affect how medicines are bought to market, create lag times and cause the supply of medicines in some areas of the globe to be delayed long after they are available elsewhere. High prices, misuse of drugs and poor or unreliable drug quality contribute to this issue. More @Wikipedia
Hover over any link to get a description of the article. Please note that search keywords are sometimes hidden within the full article and don't appear in the description or title.