Major interstate ramps will be closed this weekend as work on the downtown Louisville portion of the Ohio River Bridges Project moves forward. Two heavily traversed interstate ramps in Spaghetti Junction will close at about 9 p.m. Friday, Oct. 24, and reopen by 11 a.m. Sunday, Oct. 26, according to a news release from the Ohio River Bridges Project. The closures will be on the ramp from Interstate 65 north/I-65 south to Interstate 71 north and the ramp from Interstate 64 east to I-71 north. The…