This article is part of The D.C. Brief, TIME’s politics newsletter. Sign up here to get stories like this sent to your inbox. We are standing by for the most consequential 90 minutes of Kamala Harris’ political life. [time-brightcove not-tgx=”true”] With a to-do list unlike any she has stared down before and with a clock ticking as fast as any she has ever imagined, the Vice President heads into a crucible with Tuesday night’s debate against former President Donald Trump that may well dictate the final nine weeks of this race for the White House.