More than 116,000 Americans are waiting to receive an organ transplant, and about 20 die each day during the wait. Scientists are eager to find solutions to the organ shortage. That’s why a recent landmark report in the journal Science, which detailed the creation of piglets that could potentially provide organs for human transplants in the future, is being heralded as a “real game changer.” Researchers from Harvard University, the biotech company eGenesis and other institutions explained how they used cloning and the gene-editing technology CRISPR to create pigs that may be used for human organ transplants down the line—if further research proves them safe and effective.