DELAFIELD, Wis. (Stockpickr) -- Trading stocks that trigger major breakouts can lead to massive profits. Once a stock trends to a new high or takes out a prior overhead resistance point, then it's free to find new buyers and momentum players who can ultimately push the stock significantly higher. >>5 Sin Stocks to Play Defense in 2014 One example of a successful breakout trade I flagged recently was biopharmaceutical player Sarepta Therapeutics , which I featured in Nov.