By Rachael Rettner, Senior Writer Published: 04/16/2014 08:34 AM EDT on LiveScience People with certain personality traits may be at increased risk for drug use problems, and studying personality may help researchers better understand and treat these problems, according to a new review. Many studies have attempted to link genes to the condition researchers call substance use disorder, but they've largely failed to do so, even though the condition can run in families, said Dr.