Interstate 25 will be closed between U.S. 24/Cimarron Street and South Nevada Avenue next weekend as crews continue work on the highway interchange project there. Both directions of I-25 will be closed, starting at 11 p.m. Nov. 14 and continuing until 6 a.m. Nov. 15, to allow Colorado Springs Utilities to relocate overhead power lines, according to a new release from the Colorado Department of Transportation.