Odrisamer Despaigne pitched eight strong innings and Will Middlebrooks homered and drove in three runs in the San Diego Padres' 7-1 win over Pittsburgh on Sunday night. If Hurdle is thinking about making a change, reliever Vance Worley made a great case by throwing four scoreless innings while allowing five hits and striking out four. Middlebrooks homered off Locke in a three-run third inning and added a sacrifice fly in the fourth. Jed Gyorko had a two-run single in the first inning and Clint Barmes had three hits and an RBI. Pirates: RHP Gerrit Cole, who has allowed two or fewer earned runs in eight of his 10 starts, gets the starts when Pittsburgh opens a three-game series Monday night at San Francisco. Padres: RHP Andrew Cashner (3-7), who averages the lowest run support (2.30 runs) of any starting pitcher in the majors, will take the mound Monday night when San Diego hosts the New York Mets in a three-game series.