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Bookmark or Share- The Human Genome Project: Lessons from Large-Scale Biology | Science - AAASThe Human Genome Project has been the first major foray of the biological and medical research communities into “big science.” In this Viewpoint, we present some of our experiences in organizing and managing such a complicated, publicly funded, international effort.
- The complete sequence of a human genome | Science - AAASAddressing the remaining 8% of the genome, the Telomere-to-Telomere (T2T) Consortium presents a complete 3.055 billion–base pair sequence of a human genome, T2T-CHM13, that includes gapless assemblies for all chromosomes except Y, corrects errors in the prior references, and introduces nearly 200 million base pairs of sequence containing 1956 ...
- The legacy of the Human Genome Project | Science - AAASA reference human genome sequence has itself proved a critical research tool. Basic lab experiments today are unimaginable without it: from designing primers for molecular cloning to genetic manipulation by small interfering RNA (siRNA) or CRISPR-Cas9–based guide RNAs.
- The Human Genome | Science - AAASBy comparing the human genome with expressed sequence tags and with other genomic and protein data, researchers have figured out that human genes do more work than those in other organisms do—and therein may lie the difference between us and them.
- The Sequence of the Human Genome | Science - AAASDecoding of the DNA that constitutes the human genome has been widely anticipated for the contribution it will make toward understanding human evolution, the causation of disease, and the interplay between the environment and heredity in defining the human condition.
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