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Bookmark or Share- Cold Agglutinin Disease: What It Is, Symptoms & TreatmentCold agglutinin disease (CAD) is a rare blood condition that occurs when your immune system attacks your red blood cells. Your immune system makes proteins called antibodies that destroy harmful germs that enter your body. With CAD, your immune system releases an autoantibody, or “cold agglutinin,” that attacks healthy red blood cells.
- Cold Agglutinin Disease: Causes, Symptoms, and Treatments - WebMDCold agglutinin disease (CAD) is a condition that makes your body’s immune system attack your red blood cells and destroy them. It’s triggered by cold temperatures, and it can cause problems...
- Cold agglutinin disease - WikipediaCold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below 30 °C (86 °F), [1] directed against red blood cells, causing them to agglutinate and undergo lysis. [2]
- Diagnosis and Treatment of Cold Agglutinin DiseaseCR Immunoglobulin M (IgM) is the antibody that binds to the surface of the red blood cells in cold agglutinin disease, so therapy focuses on suppressing the production of this antibody.
- Cold agglutinin disease - UpToDateCold agglutinin disease (CAD) is a form of autoimmune hemolytic anemia (AIHA) in which cold agglutinins (IgM autoantibodies against red blood cell [RBC] antigens that bind at cold temperatures) can cause clinical symptoms related to RBC agglutination in cooler parts of the body and hemolytic anemia.
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