Safe but not advised: Benadryl (diphenhydramine) is too sedating, resulting often in some cognitive suppression. The reason for taking the Vyvanse in the 1st place is to enhance cognition. There are better antihistamines. And, if the purpose of the Benadryl (diphenhydramine) is to help sleep at night, there are better choices. Dr Ali and 8 ... More @Wikipedia
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