Arquette is a respected indie veteran (Tony Scott's "True Romance," David Lynch's "Lost Highway," Martin Scorsese's "Bringing Out the Dead") who has never been nominated for an Oscar (she won an Emmy for "Medium" in 2005) and is overdue. She has more screen time than anyone besides title star Ellar Coltrane, aging over 12 years and enduring a series of often abusive husbands.