Investing in high-growth stocks can be both exciting and financially rewarding. But the largest returns are reserved for patient investors who buy shares of great businesses early, then hold on for the long term.Shopify (NYSE: SHOP) is one such business that illustrates that point nicely. Shares of the leading e-commerce platform provider have soared more than 400% since shortly after its mid-2015 initial public offering -- and this despite falling into the crosshairs of a noted short-seller late last year.Of course, many investors believe that, with e-commerce still in its earliest stages, Shopify still has room to run in the coming years.